| Product Name | SLIGKV-NH2 |
|---|---|
| Description |
SLIGKV-NH2 is a protease-activated receptor 2 (PAR2) agonist with a Ki of 9.64 μM and an IC50 of 10.4 μM. SLIGKV-NH2 corresponds to the tethered ligand exposed by trypsin cleavage of PAR-2 and like other peptides corresponding to the tethered ligand sequences of the thrombin receptor and PAR-2 receptor is a full agonist and can be used to investigate receptor function. SLIGKV-NH2 stimulates lactoferrin and IL-8 secretion from human neutrophils.
|
| Synonyms | 190383-13-2, SLIGKV-NH2 |
| Molecular Weight | 614.78 Da |
| Target | Protease activated receptors |
| Amino Acid Sequence | SLIGKV-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 190383-13-2 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide) |
| References |
Bohm et al (1996) Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem.J. 314 1009 PMID: 8615752Wang and He (2006) Induction of lactoferrin and IL-8 release from human neutrophils by tryptic enzymes via proteinase activated receptor-2. Cell Biol Int. 30(9) 688 PMID: 16820307Kennedy et al (2018) Structural Characterization of Agonist Binding to Protease-Activated Receptor 2 through Mutagenesis and Computational Modeling. ACS Pharmacol Transl Sci. 1(2) 119 PMID: 32219208 Related data All peptides >All protease activated receptors >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
