| Product Name | SLIGRL-NH2 |
|---|---|
| Description |
SLIGRL-NH2 is an agonist peptide derived from the N-terminus (aas 39-44) of protease-activated receptor 2 (PAR2). SLIGRL-NH2 activates PAR2 with an EC50 of approximately 5 μM and through its effects on PAR2 it stimulates gastric and intestinal smooth muscle contraction. SLIGRL-NH2 is a pruritogen and causes scratching behaviour in mice. |
| Synonyms | PAR-2 activation peptide, SL-NH2 |
| Molecular Weight | 656.82 Da |
| Target | Protease activated receptors |
| Amino Acid Sequence | SLIGRL-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 171436-38-7 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Al-Ani et al (1995) Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can.J.Physiol.Pharmacol. 73 1203 PMID: 8564891Chung et al (2019) Cathepsin S acts via protease-activated receptor 2 to activate sensory neurons and induce itch-like behaviour, Neurobiology of Pain 6 100032 https://doi.org/10.1016/j.ynpai.2019.100032Wang et al (2021) Protease-Activated Receptor-2 Decreased Zonula Occlidens-1 and Claudin-1 Expression and Induced Epithelial Barrier Dysfunction in Allergic Rhinitis. American J. Rhinology & Allergy 35(1) 26 PMID: 32551923 Related data All peptides >All protease activated receptors >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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