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|Product Name||SLPI, 26-132aa, Human|
|Background||SLPI is a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity. Recombinant human SLPI, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
|Synonyms||Antileukoproteinase, ALK1, ALP, BLPI, HUSI, HUSI-I, MPI, WAP4, WFDC4, secretory leukocyte peptidase inhibitor, ALK 1, Antileukoproteinase 1, Antileukoproteinase1, HUSI 1, HUSI I, Protease inhibitor WAP4, Secretory leukocyte protease inhibitor, Seminal proteinase inhibitor, WAP four disulfide core domain protein 4, WAP 4, WFDC 4|
|AA Sequence||MGSSHHHHHH SSGLVPRGSH MSGKSFKAGV CPPKKSAQCL RYKKPECQSD WQCPGKKRCC PDTCGIKCLD PVDTPNPTRR KPGKCPVTYG QCLMLNPPNF CEMDGQCKRD LKCCMGMCGK SCVSPVKA|
|Molecular Weight||37 kDa(337aa), confirmed by MALDI-TOF|
|Form||Liquid, in 20 mM Tris-HCl Buffer (pH 8.0) containing 20% Glycerol|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Purity||> 80% by SDS-PAGE|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Rasool N., et al. (2010) Clin Cancer Res. 16(2):600-9
King AE., et al. (2009) Hum Reprod. 24(3):679-86.
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