| Product Name | SMYD3 Monoclonal Antibody |
|---|---|
| Description | SMYD3,also name as ZMYND1 and ZNFN3A1,belongs to the histone-lysine methyltransferase family.It is a histone methyltransferase that plays an important role in transcriptional regulation in human carcinogenesis. It can specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes,including several oncogenes (e.g.,N-myc,CrkL,Wnt10b,RIZ and hTERT) and genes involved in the control of cell cycle.. It plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD3 is frequently overexpressed in different types of cancer cells. It functions as a coactivator of Era and potentiates Era activity in response to ligand. SMYD3 as a new coactivator for ER-mediated transcription,providing a possible link between SMYD3 overexpression and breast cancer. The common variable number of tandem repeats polymorphism in SMYD3 is a susceptibility factor for some types of human cancer. . |
| Synonyms | bA74P14.1,FLJ21080,SMYD3,ZMYND1,ZNFN3A1 |
| Host | Mouse |
| Clone | 1B5C10 |
| Immunogen | Fusion Protein of SMYD3 |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | ELISA, IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | Q9H7B4 |
| Background | SMYD3,also name as ZMYND1 and ZNFN3A1,belongs to the histone-lysine methyltransferase family.It is a histone methyltransferase that plays an important role in transcriptional regulation in human carcinogenesis. It can specifically methylate histone H3 at lysine 4 and activate the transcription of a set of downstream genes,including several oncogenes (e.g.,N-myc,CrkL,Wnt10b,RIZ and hTERT) and genes involved in the control of cell cycle.. It plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD3 is frequently overexpressed in different types of cancer cells. It functions as a coactivator of Era and potentiates Era activity in response to ligand. SMYD3 as a new coactivator for ER-mediated transcription,providing a possible link between SMYD3 overexpression and breast cancer. The common variable number of tandem repeats polymorphism in SMYD3 is a susceptibility factor for some types of human cancer. . |
| Supplier | Elabscience |
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