| Product Name | SNAPC1, 1-368aa, Human (Denatured) |
|---|---|
| Description | SNAPC1 is a part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. It binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Also, it recruits TBP and BRF2 to the u6 snRNA TATA box. Recombinant human SNAPC1 protein, fused to His-tag at N-terminus, was expressed in E.coli |
| Synonyms | snRNA-activating protein complex subunit1, PTFgamma, SNAP43 |
| Host | E. coli |
| Molecular Weight | 39.5 kDa (377aa) confirmed by MALDI-TOF |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMGTPPGL QTDCEALLSR FQETDSVRFE DFTELWRNMK FGTIFCGRMR NLEKNMFTKE ALALAWRYFL PPYTFQIRVG ALYLLYGLYN TQLCQPKQKI RVALKDWDEV LKFQQDLVNA QHFDAAYIFR KLRLDRAFHF TAMPKLLSYR MKKKIHRAEV TEEFKDPSDR VMKLITSDVL EEMLNVHDHY QNMKHVISVD KSKPDKALSL IKDDFFDNIK NIVLEHQQWH KDRKNPSLKS KTNDGEEKME GNSQETERCE RAESLAKIKS KAFSVVIQAS KSRRHRQVKL DSSDSDSASG QGQVKATRKK EKKERLKPAG RKMSLRNKGN VQNIHKEDKP LSLSMPVITE EEENESLSGT EFTASKKRRK H |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in PBS buffer (pH 7.4) containing 20% glycerol, 1mM DTT, 0.1mM PMSF |
| Concentration | 0.25 mg/ml (determined by Bradford assay) |
| Purity | > 80 % by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Hinkley C.S., et al. (2003) J. Biol. Chem. 278:18649-18657. |
| Background | SNAPC1 is a part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. It binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Also, it recruits TBP and BRF2 to the u6 snRNA TATA box. Recombinant human SNAPC1 protein, fused to His-tag at N-terminus, was expressed in E.coli |
| Supplier | ARP |
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