| Product Name | SOR-C13 |
|---|---|
| Description |
SOR-C13 is a carboxy terminal truncated peptide derived from the 54 residue paralytic peptide soricidin, found in the paralytic venom of the short-tailed shrew Blarina brevicauda. SOR-C13 is a high affinity, use dependent antagonist of human transient receptor potential vanilloid 6 (TRPV6) channels with an IC50 of 14 nM. TRPV6 is a non-voltage gated calcium channel implicated in malignancies and poor prognosis in breast cancer. In vivo, SOR-C13 reduces the growth of human ovarian xenografts in NOD/SCID mouse models.
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| Synonyms | 1187852-48-7, KEFLHPSKVDLPR, SOR-C13, TP-020 |
| Molecular Weight | 1565.81 Da |
| Target | Transient receptor potential (TRP) channels |
| Amino Acid Sequence | KEFLHPSKVDLPR |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 1187852-48-7 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Bowen et al (2013) In vivo detection of human TRPV6-rich tumors with anti-cancer peptides derived from soricidin. PLoS One 8(3) e58866 PMID: 23554944Xue et al (2018) Inhibition of Transient Receptor Potential Vanilloid 6 channel, elevated in human ovarian cancers, reduces tumour growth in a xenograft model. J Cancer 9(17) 3196 PMID: 30210643 Related dataAll peptides >All transient receptor potential (TRP) channel modulators >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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