| Product Name | Spexin |
|---|---|
| Description |
Spexin, or neuropeptide Q, is an endogenous galanin receptor 2/3 agonist with EC50 values of 45 and 112 nM respectively, and no significant activity at galanin receptor 1. Spexin is a satiety inducing peptide which inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet induced obese mice and rats. Spexin gene expression is markedly down regulated in obese human fat. Spexin also posseses anxiolytic properties. |
| Synonyms | Neuropeptide Q, NPQ, Spexin (36 - 49) amidated |
| Molecular Weight | 1619.9 Da |
| Target | Galanin receptors |
| Amino Acid Sequence | NWTPQAMLYLKGAQ-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 1370290-58-6 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Walewski et al (2014) Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. Obesity 22(7) 1643 PMID: 24550067Kim et al (2014) Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology 155(5) 1864 PMID: 24517231Shuang-Yu et al (2019) Emerging Roles of NPQ/Spexin in Physiology and Pathology. Frontiers in Pharmacology 10 457 PMID: 31133851 Related areas All peptides >All galanin receptor modulators >All neuroscience research categories >All appetite regulation research categories >All endocrinology research categories > |
| Supplier | Isca Biochemicals Limited |
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