| Product Name | SRC-1 (676-700), biotinylated |
|---|---|
| Description | SRC-1 (676–700), biotinylated, also known as biotin-SRC-1, or biotinylated steroid receptor coactivator-1 peptide, is a biotinylated 25-mer peptide derived from amino acids 676-700 of the transcriptional coregulatory protein human nuclear receptor coactivator SRC-1. SRC-1 (676–700), biotinylated has been used in AlphaScreen, time-resolved fluorescence (TRF), and time-resolved fluorescence energy transfer (TR-FRET) assays for various nuclear receptors including assays for the ROR family proteins RORα, RORβ and RORγt, a farnesoid X receptor (FXR) assay, and human PPARα, PPARγ, and PPARδ assays. SRC-1 (676–700), biotinylated contains a covalently bonded N-terminal biotin tag that can be used for detection and purification. |
| Synonyms | Biotin-SRC-1, Biotinylated steroid receptor coactivator-1 peptide |
| Molecular Weight | 3127.22 Da |
| Target | Nuclear receptor modulators |
| Amino Acid Sequence | Biotin-CPSSHSSLTERHKILHRLLQEGSPS |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: N terminal is biotinylated |
| References |
Wu et al (2003) Comparison of Assay Technologies for a Nuclear Receptor Assay Screen Reveals Differences in the Sets of Identified Functional Antagonists. J. Biomol. Screen. 8(4) 381 PMID: 14567790Chen et al (2010) Cevoglitazar, a Novel Peroxisome Proliferator-Activated Receptor-α/γ Dual Agonist, Potently Reduces Food Intake and Body Weight in Obese Mice and Cynomolgus Monkeys, Endocrinology 151(7) 3115 PMID: 20484464Yang et al (2019) Discovery of betulinaldehyde as a natural RORγt agonist. Fitoterapia 137 104200 PMID: 31195082 Related areas All biotin labelled peptides >All nuclear receptor modulators > |
| Supplier | Isca Biochemicals Limited |
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