| Product Name | ssK36 |
|---|---|
| Description | ssK36, or ssK36 (29–43), is a SET-domain containing protein 2 (SETD2) super substrate. SETD2, also called KMT3A, was first identified as huntingtin interacting protein 1 (HYPB, HIP-1) and can add up to three methyl groups to K36 of histone H39 (H3K36). ssK36 (29-43 has been derived from the currently used SETD2 substrate peptide H3K36 (29-43) but is methylated about 290-fold faster, making it a super substrate. The increased methylation of ssK36 is due to an increase in the rate of catalysis and only to a smaller degree to improved binding. |
| Synonyms | ssK36 (29-43) |
| Molecular Weight | 1771 Da |
| Target | Transferases |
| Amino Acid Sequence | APRFGGVKRPNRYRP |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: None |
| References |
Schuhmacher et al (2020) Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate. Commun. Biol. 3(1) 511 PMID: 32939018 Related areasAll substrate peptides >All epigenetic research categories > |
| Supplier | Isca Biochemicals Limited |
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