| Product Name | STIM1 Monoclonal Antibody |
|---|---|
| Description | STIM1,also named as GOK,is an ER Ca2+ sensor. Upon Ca2+ store depletion,STIM1 clusters at ERÐplasma membrane junctions where it interacts with and gates Ca2+-permeable Orai1 ion channels. STIM1 is implicated in tumor growth suppression and stromal-haematopoietic cell interactions. Defacts in STIM1 gene can cause immune dysfunction with impaired T-cell activation. STIM1 can inhibit L-type voltage-gated Ca(2+) channels in neurons. Temperature is an important regulator of STIM1 function.The MW of STIM1 is about 80-90 kDa which may be due to the phosphorylation or glycosylation forms. |
| Host | Mouse |
| Clone | 57 |
| Immunogen | Fusion protein of STIM1 |
| Isotype | IgG2a |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | Q13586 |
| Background | STIM1,also named as GOK,is an ER Ca2+ sensor. Upon Ca2+ store depletion,STIM1 clusters at ERÐplasma membrane junctions where it interacts with and gates Ca2+-permeable Orai1 ion channels. STIM1 is implicated in tumor growth suppression and stromal-haematopoietic cell interactions. Defacts in STIM1 gene can cause immune dysfunction with impaired T-cell activation. STIM1 can inhibit L-type voltage-gated Ca(2+) channels in neurons. Temperature is an important regulator of STIM1 function.The MW of STIM1 is about 80-90 kDa which may be due to the phosphorylation or glycosylation forms. |
| Supplier | Elabscience |
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