| Product Name | STX4, 1-275aa, Human |
|---|---|
| Description | Syntaxin 4, also known as STX4, belongs to thesyntaxin/epimorphin family of proteins. Syntaxin family is cellular receptors for transport vesicles which participate in exocytosis in neutrophils. Syntaxin 4 is crucial for normal insulin-stimulated glucose uptake in skeletal muscle and decreases in Syntaxin 4 protein levels result in reduction of whole-body insulin-stimulated glucose metabolism. Recombinant human STX4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | Syntaxin 4, p35-2, STX4A |
| Host | E. coli |
| Molecular Weight | 25.6kDa (234aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher) |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMMRDRT HELRQGDDSS DEEDKERVAL VVHPGTARLG SPDEEFFHKV RTIRQTIVKL GNKVQELEKQ QVTILATPLP EESMKQELQN LRDEIKQLGR EIRLQLKAIE PQKEEADENY NSVNTRMRKT QHGVLSQQFV ELINKCNSMQ SEYREKNVER IRRQLKITNA GMVSDEELEQ MLDSGQSEVF VSNILKDTQV TRQALNEISA RHSEIQQLER SIRELHDIFT FLATEVEMQG EMINRIEKNI LSSADYVERG QEHVKTALEN QKKARKKKVL |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20 mM Tris-HCl buffer, pH 8.0, 10% glycerol, 0.2mM PMSF, 100mM NaCl |
| Concentration | 1mg/ml (determined by Bradford assay) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Yang C., et al. (2001) J Clin Invest. 107: 1311-1318 Bennett M K., et al. (1993) Cell. 74: 863-873. |
| Background | Syntaxin 4, also known as STX4, belongs to thesyntaxin/epimorphin family of proteins. Syntaxin family is cellular receptors for transport vesicles which participate in exocytosis in neutrophils. Syntaxin 4 is crucial for normal insulin-stimulated glucose uptake in skeletal muscle and decreases in Syntaxin 4 protein levels result in reduction of whole-body insulin-stimulated glucose metabolism. Recombinant human STX4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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