| Product Name | Substance P |
|---|---|
| Description | Substance P, also known as neurokinin-1, is a widely distributed 11-amino acid neuropeptide that preferentially activates the neurokinin-1 receptor (NK1R) and exerts excitatory effects on central and peripheral neurons and is involved in pain transmission. Substance P is also expressed by a variety of non-neuronal cell types such as microglia and immune cells and it stimulates mast cell degranulation and histamine release, proliferation and differentiation of lymphocytes, and induces immunoglobulin synthesis. Substance P dysregulation is associated with inflammatory diseases and obesity. |
| Synonyms | Neurokinin-1 |
| Molecular Weight | 1347.6 Da |
| Target | Tachykinin receptors |
| Amino Acid Sequence | RPKPQQFFGLM-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 33507-63-0 |
| Storage | We recommend storage desiccated, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Andoh et al (1998) Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J.Pharmacol.Exp.Ther. 286 1140 PMID: 9732370Walsh et al (1995) Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators. Br.J.Pharmacol. 114 1343 PMID: 7541689Zieglgänsberger (2019) Substance P and pain chronicity. Cell Tissue Res. 375(1) 227 PMID: 30284083 Related Areas All peptides >All tachykinin receptor modulators >All pain research categories >All neuroscience research categories >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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