ACBP, 1-87aa, Human

Proteins, Recombinant
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Product Name ACBP, 1-87aa, Human
Background ACBP, also known as ACBD1, is a diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. Expression of ACBP is significantly induced during adipocyte differentiation. ACBP is a target for proliferator-activated receptor (PPAR)gamma, and is directly activated by PPARgamma/RXRalpha and PPARalpha/RXRalpha, but not by PPARdelta/RXRalpha. Recombinant human ACBP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms ACBD1, CCK-RP, EP, DBI, Acyl-CoA-binding protein, Diazepam Binding Inhibitor Protein
Species Human
Molecular Weight 16.3 kDa(142aa), confirmed by MALDI-TOF
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_001073331
Host E.coli
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Folli F., et al. (2010) PLoS One. 5(3):e9923.
Manjithaya R., et al. (2010) J Cell Biol. 188(4):537-46.

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