| Product Name | AKR1B10, 1-316aa, Human, Recombinant |
|---|---|
| Description | AKR1B10, also known as Aldo-keto reductase family 1, member B10, AKR1B10 is a monomeric protein that efficiently catalyzes the reduction of aromatic and aliphatic aldehydes and ketones. AKR1B10 is ubiquitously expressed in many human tissues but is highly expressed in small intestine, colon and adrenal gland. This protein is pathogenically involved in diabetic complications and has been reported that AKR1B10 is overexpressed in human tumors, such as liver, breast, and lung cancer, and may play a critical role in the development and progression of cancer. Recombinant human AKR1B10 protein was expressed in E.coli and purified by using conventional chromatography. |
| Synonyms | AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HIS, Aldo-keto reductase family 1, member B10, AKR1B10, Aldo-keto reductase family 1, member B10 Aldose reductase like, Aldose reductase related protein, ARL 1, hARP, SI reductase, Small intestine reductase. |
| Host | E.coli |
| Molecular Weight | 12.8 kDa (114aa), confirmed by MALDI-TOF. |
| Amino Acid Sequence | MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ NEHEVGEAIQ EKIQEKAVKR EDLFIVSKLW PTFFERPLVR KAFEKTLKDL KLSYLDVYLI HWPQGFKSGD DLFPKDDKGN AIGGKATFLD AWEAMEELVD EGLVKALGVS NFSHFQIEKL LNKPGLKYKP VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK HKKTAAQVLI RFHIQRNVIV IPKSVTPARI VENIQVFDFK LSDEEMATIL SFNRNWRACN VLQSSHLEDY PFDAEY |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
| References |
Yabe D., et al. (1997) J Biol Chem. 272(29):18232-9. Vorum H., et al. (1998) Biochim Biophys Acta. 1386(1):121-31. |
| Supplier | ARP |
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