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|Product Name||Annexin A5, 1-320aa, Human|
|Background||Annexin A5, also known as Annexin V, belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin A5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Recombinant Annexin A5 protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||Annexin V, ANX5, ENX2, PP4, Anchorin CII, Annexin 5, Annexin A5, ANX A5, Calphobindin I, Endonexin II, Lipocortin V, PAP I, Placental anticoagulant protein I.|
|Amino Acid Sequence||MAQVLRGTVT DFPGFDERAD AETLRKAMKG LGTDEESILT LLTSRSNAQR QEISAAFKTL FGRDLLDDLK SELTGKFEKL IVALMKPSRL YDAYELKHAL KGAGTNEKVL TEIIASRTPE ELRAIKQVYE EEYGSSLEDD VVGDTSGYYQ RMLVVLLQAN RDPDAGIDEA QVEQDAQALF QAGELKWGTD EEKFITIFGT RSVSHLRKVF DKYMTISGFQ IEETIDRETS GNLEQLLLAV VKSIRSIPAY LAETLYYAMK GAGTDDHTLI RVMVSRSEID LFNIRKEFRK NFATSLYSMI KGDTSGDYKK ALLLLCGEDD|
|Molecular Weight||28.3 kDa (244aa), confirmed by MALDI-TOF.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in Phosphate buffered saline (pH7.4) , 10% glycerol|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_001145.1|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Frey B., et al. (2009) J Immunotoxicol. 6(4):209-16.
Steele AJ., et al. (2009) Blood. 114(6):1217-25.
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