| Product Name | Anti-Alpha 6 Integrin, CD49f Monoclonal Antibody |
|---|---|
| Description | The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. In cutaneous melanocytic lesions, the level of expression of three Integrin subunits (alpha 2, alpha 6, beta 3) has been found to be correlated with tumor progression. |
| Synonyms | CD49f, VLA-6, ITGA6B |
| Clone | GoH3 |
| Immunogen | Mouse mammary tumor cells |
| Isotype | Rat IgG2a |
| Specificity | Mab GoH3, directed against alpha6 Integrins (Laminin receptor, VLA-6) shows a cytoplasmic staining pattern of uveal and cutaneous melanoma cells |
| Reactivity | Human |
| Applications | FC, IHC, WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | ten Berge, PJM et al. (1993) Investigative Ophthalmology & Visual Science Vol 34, No. 13. Sonnenberg A et al. (1987) J Biol Chem 262: 10376-10383Bosman FT et al. (1993) Int J Dev Biol 37: 203-211Bosnan FT. et al. (1993) Histochem J 25: 469-477 |
| Supplier | ARP |
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