| Product Name | Anti-CD45 (clone 2H12) Monoclonal Antibody |
|---|---|
| Description | CD45 belongs to a family of heavily glycosylated, high molecular weight transmembrane glycoproteins expressed on all cells of haematopoietic origin. Structurally heterogeneous, CD45 consists of a family of eight isoforms ranging from 180,000 to 220,000 MW generated by alternative splicing of three exons differentially expressed on subpopulation of lymphocytes. CD45 protein tyrosine phosphatase activity plays a central role in T-cell activation. CD45 plays an important role in signal transduction inhibition or upregulation of various immunological functions. |
| Synonyms | protein tyrosine phosphatase, receptor type, C (PTPRC), CD45 |
| Host | Mouse |
| Clone | 2H12. Anti-human CD45 mAb, clone 2H12, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CD45 protein. |
| Immunogen | Recombinant human CD45 (1029-1249aa) purified from E. coli |
| Isotype | K,IgG2b |
| Reactivity | Human, Mouse |
| Applications | ELISA, FACS |
| Form | Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide. |
| Storage | Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
| References | Evgueni k , et al., (2005) Immunogenetics 57(5):374-383 Holmes N., (2006) Immunology 117(2):145-155 Francois S , et al., (2004) Immunology 113(4):441-452 Tara S , et al., (2003) Proc Natl Acad Sci U S A 100(10):5997-6002 |
| Supplier | ARP |
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