| Product Name | Anti-Clathrin Monoclonal Antibody |
|---|---|
| Description | Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. Mouse monoclonal antibody to Clathrin. Polypeptide reacting: Mr 180 000 polypeptide (clathrin heavy chain) from coated vesicles of various tissues. |
| Synonyms | Hc, CHC, CHC17, CLH-17, CLTCL2 |
| Clone | CHC5.9 |
| Immunogen | Coated vesicles (clathrin) of bovine brain |
| Isotype | IgM |
| Specificity | CHC5.9 represents an excellent marker for detection of receptor mediated endocytosis (for review cf. e.g. refs. 2 and 3) |
| Reactivity | Amphibian, Bovine, Human, Porcine, Rat |
| Applications | IHC, WB |
| Form | Purified (Gel Filtration), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| References | Bruder, G. & Wiedenmann, B. (1986). Exp. Cell Res. 164: 449-462Hirst J. & Robinson, MS (1998) Biophys Acta 1404: 173-193Qualmann,B et al. (2000) J Cell Biol 150: F111-F116 |
| Supplier | ARP |
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