| Product Name | Anti-Complement C5b (neoepitope) Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. Mouse Monoclonal Antibody to Complement C5b neoepitope. Detection of C5b-9 complexes via activated C5, whereas native C5 reacts with antibody HCC5.1 (cat.#: 03-61021). Polypeptide reacting: MR 200,000 of SDS denatured complement component C5 and C5b of MR 185,000; after C5b activation, a MR 60,000 cleavage products also reacts (weak). |
| Synonyms | C5a, C5b, CPAMD4 |
| Clone | HCC5b.1 (neo) |
| Immunogen | Activated human complement component C5 |
| Isotype | IgG1 |
| Specificity | HCC5b.1 (neo) allows detection of C5b-9 complexes via activated C5, especially in different forms of glomerulonephritis. Does not react with native C5 |
| Reactivity | Bovine, Goat, Human, Porcine, Primate |
| Applications | ELISA, IHC, WB |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| References | Moongkarndi, P.et al. (1983) Immunobiol. 165: 323ppMoongkarndi, P.et al. (1982). Immunobiol. 162: 397pp |
| Supplier | ARP |
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