| Product Name | Anti-Cytokeratin/Keratin Type II, Monoclonal Antibody, FITC |
|---|---|
| Description | Type II keratins (or Type II cytokeratins) constitutes the Type II intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells. The type 2 cytokeratins consist of basic or neutral, high molecular weight proteins which in vivo are arranged in pairs of heterotypic Type I and Type II keratin chains, coexpressed during differentiation of simple and stratified epithelial tissues. Polypeptide reacting: Mr 53 000 to Mr 67 000 basic type II keratin polypeptides of human epithelial proteins (keratins ‰â‰ÛÏ formerly also designated cytokeratins - nos. K1 ‰â‰ÛÏ K8). Epitope has been mapped to aa 266-299 on alpha-helical rod domain. Ks pan 1-8 represents an excellent marker for distinguishing carcinomas from non-epithelial tumors. Polypeptides reacting: Mr 52 500 - Mr 68 000 keratins (type II keratins K1 - K8; formerly also designated cytokeratins 1 - 8) of human epithelial cells. |
| Clone | Ks pan 1-9 |
| Immunogen | Cytoskeletal proteins from cultured human MCF-7 cells |
| Isotype | IgG2a |
| Specificity | Tumors specifically detected: all epithelium-derived neoplasms |
| Reactivity | Amphibian, Bovine, Human |
| Applications | IF |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| References | AchtstÌÄå_tter, Th et al. (1989) Differentiation 40: 129-149Gould, V.E. et al. (1989) Am. J. Pathol. 137: 1143-1155Heid, H.W.et al. (1988) Differentiation 37: 137-157Moll, R.et al. (1982) Cell 31: 11-24 |
| Supplier | ARP |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
