Anti-Desmoplakin 1/2 Multi-Epitope Cocktail Monoclonal Antibody
| Product Name | Anti-Desmoplakin 1/2 Multi-Epitope Cocktail Monoclonal Antibody |
|---|---|
| Description | Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. Mouse Monoclonal Antibody to Multi-Epitope Cocktail to Desmoplakin 1&2. Polypeptide reacting: Desmoplakins 1 and 2 (Mr 250.000 and 215.000) |
| Synonyms | DP, DPI, DPII |
| Clone | DP1&2-2.15; DP1-2.17; DP1&2-2.20 |
| Immunogen | Bovine desmoplakins 1 & 2 |
| Isotype | All IgG1 |
| Specificity | The antibody cocktail shows distinct punctate membrane staining of different epithelia and the aerea composite of the myocard. Tumors specifically detected: Primary and metastatic cancer; meningioma |
| Reactivity | Gallus, Bovine, Canine, Human, Mouse, Rat |
| Applications | WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Cowin, P. et al. (1985). J. Cell Biol. 101: 1442-1454Dockhorn-Dworniczak, B et al. (1987). Differentiation 35: 53-71Franke, W.W. et al. (1983) Proc. Natl. Acad. Sci., USA, 80: 543-547Moll, R. et al. (1986) Lab. Invest. 54: 4-25.Koch, P.J. et al. (1990) Eur. J. Cell Biol. 53: 1-12Moll, I. and Moll, R. (1991) Arch Dermatol Res. 283: 300-309Owaribe, K.et al. (1990) Differentiation 45: 207-220Owaribe, K. et al. (1991) Exp. Cell Rev. 192: 622-630Hatzfeld, M. et al. (2000) J. Cell Biol. 149: 209-2222 |
| Supplier | ARP |
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