| Product Name | Anti-LRP/a2MR (85 kDa); CD92 Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. Mouse Monoclonal Antibody to LRP/a2MR (85 kDa); CD92 |
| Synonyms | CD92, CDW92, CHTL1, CTL1, RP11-287A8.1 |
| Clone | 8B8 |
| Isotype | IgG1 |
| Specificity | 8B8 specifically reacts with the 85 kD beta-chain of human LRP/alpha2MR which is expressed in a restricted spectrum of cell types (for a recent review cf. Herz & Strickland). A strong immunohistochemical reaction is seen in hepato- cytes, tissue macrophages, subsets of neurones and as- trocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in athero- sclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelo- monocytic subtypes of chronic and acute leukemia (CD 91) |
| Reactivity | Hamster, Human, Mouse, Rabbit, Rat |
| Applications | FC, IF, IHC, WB |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| References | Strickland, et al. (1990) J. Biol. Chem. 265: 17401-17404Basu S et al. (2003) Blood 101: 2810-2815Herz J & Strickland DK (2001) Immunity 14: 303-313Misra UK et al. (1999) Arch Biochem Biophys 372: 238-247 |
| Supplier | ARP |
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