Anti-Multi-Epitope Cocktail toNucleolar Organizer Region (NOR) / TCOF1 (Treacle Protein) Monoclonal Antibody
| Product Name | Anti-Multi-Epitope Cocktail toNucleolar Organizer Region (NOR) / TCOF1 (Treacle Protein) Monoclonal Antibody |
|---|---|
| Description | The nucleolus organizer region (NOR) or nucleolar organizer is a chromosomal region around which the nucleolus forms. This region is the particular part of a chromosome that is associated with a nucleolus after the nucleus divides. The region contains several tandem copies of ribosomal DNA genes. In humans, the NOR contains genes for 5.8S, 18S, and 28S rRNA clustered on the short arms of chromosomes 13, 14, 15, 21 and 22 (the acrocentric chromosomes). Treacle protein is a protein that in humans is encoded by the TCOF1 gene. This gene encodes a nucleolar protein with an LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mouse Monoclonal Antibody to Multi-Epitope Cocktail to Nucleolar Organizer Region (NOR) / TCOF1 (Treacle Protein). Polypeptide reacting: Mr 240 kD band in SDS gels and lower molecular weight bands (e.g. 160 kD band, Gonzales et al.) |
| Clone | X-11, X-19 |
| Immunogen | Nuclear pore complex-lamina fraction of XLKE-A6 cells (cultured cell line derived from Xenopus laevis) |
| Isotype | All IgG1 |
| Specificity | The mabs represent marker for nucleolar organizer region (NOR), putatively staining the protein treacle (described as TCOF1, cf. Gonzales et al.) |
| Reactivity | Amphibian, Gallus |
| Applications | IF, WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Derenzini M et al. (1988) Virchows Archiv B Cell Pathol 54: 334-340Gonzales B et al. (2005) Gene 359: 73-80 |
| Supplier | ARP |
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