| Product Name | Anti-P-Glycoprotein (P-gp) Monoclonal Antibody |
|---|---|
| Description | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mouse monoclonal antibody to P-Glycoprotein (P-gp) |
| Synonyms | CLCS, MDR1, P-GP, PGY1, ABC20, CD243, GP170 |
| Clone | JSB-1 |
| Immunogen | Human P-gp |
| Isotype | IgG1 |
| Specificity | Mab JSB-1 reacts with a conserved cytoplasmic epitope of the plasma membrane-associated P-glycoprotein, a 170 kD multidrug resistance-related protein. It detects P-gp overexpression in human tumor cells of all different histogenetic origins. |
| Reactivity | Hamster, Human |
| Applications | FC, WB |
| Form | Hybridoma culture Supernatant |
| Storage | 2-8C |
| References | Scheper RJ. et al. (1988) Int. J. Cancer 42: 389-394Dalton, TM. et al. J. Clin. Oncology, Vol. 7, 4: 415-424 |
| Supplier | ARP |
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