| Product Name | Anti-Thyroglobulin Monoclonal Antibody |
|---|---|
| Description | Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. Can be applied for the classification of thyroid neoplasms, especially for the differentiation between follicular and papillary carcinoma (TH-positive) and medullary carcinoma (TH-negative). Undifferentiated carcinomas will not react with the antibody. Furthermore, the antibody can be used for the characterization of metastases of unknown primary tumors. |
| Synonyms | TGN, AITD3 |
| Clone | 2H11 |
| Immunogen | Thyroglobulin isolated from human thyroid |
| Isotype | IgG1 |
| Specificity | In immunohistochemistry the antibody reacts exclusively with follicle epithelium and colloid in the thyroid. Antigen localization: membrane cytoplasm. Specifically identifies follicular epithelium of the thyroid. |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB |
| Form | Stabilized ascites containing 0.1% sodium azide |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| Supplier | ARP |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
