| Product Name | Anti-TIP47/PP17 (N-terminal) Polyclonal Antibody |
|---|---|
| Description | Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Synonyms | PP17, TIP47, M6PRBP1 |
| Immunogen | Synthetic peptide of TIP47 N-terminus (aa 1-16) |
| Specificity | The antiserum is specific for TIP47 and does not cross-react with adipophilin and perilipin or other proteins of the PAT family. |
| Reactivity | Bovine, Human |
| Applications | IHC, WB |
| Form | Stabilized Serum |
| Storage | 2-8C |
| References | Than, NG, et al. (1999) Tumor Biol. 20: 184-192Robenek, H. et al. (2005) J. Biol. Chem. 280: 5789-5794Robenek, H. et al. (2005) J. Biol. Chem. 280: 26330-26338Robenek, H. et al. (2006) Proc Natl Acad Sci USA 103: 10385-10390Straub BK et al. (2008) Hepatology 47: 1936-1946Bulankina AV et al (2009) J Cell Biol 185: 641-655Straub BK et al. (2010) Modern Pathology 23: 480-492 |
| Supplier | ARP |
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