ATOX1, 1-68aa, Human

Catalog
01-1747-1
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Proteins, Recombinant
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Product Name ATOX1, 1-68aa, Human
Background Copper transport protein ATOX1, also known as HAH1, a metal transport protein that belongs to the ATX1 family. ATOX1 is involved in cellular antioxidant defense and can bind and deliver cytosolic copper to the copper ATPase proteins. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. Recombinant human ATOX1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms Antioxidant protein 1, ATX1, HAH1, Copper transport protein ATOX1 ATX1, Copper transport protein, Metal transport protein.
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT LLATLKKTGK TVSYLGLE
Molecular Weight 60.1 kDa (551aa)
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_004036
Host E.coli
Tag GST tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Klomp LW., et al. (1997) J Biol Chem. 272(14):9221-6.
Hamzal I., et al. (1999) Proc Natl Acad Sci USA. 96(23):13363-8.

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