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|Product Name||BLOC1S2, 1-142aa, Human|
|Background||BLOC1S2 (Biogenesis of lysosome-related organelles complex 1 subunit 2) belongs to the BLOC1S2 family. BLOC-1 or biogenesis of lysosome-related organelles complex 1 is a ubiquitously expressed multisubunit protein complex. BLOC-1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. This protein plays a role in cell proliferation. Recombinant human BLOC1S2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||biogenesis of lysosomal organelles complex-1,subunit 2, BLOS2, RP11-316M21.4|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSHMAAAAE GVLATRSDEP ARDDAAVETA EEAKEPAEAD ITELCRDMFS KMATYLTGEL TATSEDYKLL ENMNKLTSLK YLEMKDIAIN ISRNLKDLNQ KYAGLQPYLD QINVIEEQVA ALEQAAYKLD AYSKKLEAKY KKLEKR|
|Molecular Weight||43.9 kDa(390aa), confirmed by MALDI-TOF|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 7.5) containing 10% glycerol 0.2M NaCl, 1mM DTT|
|Purity||> 85% by SDS-PAGE|
|NCBI Accession #||NP_776170|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Starcevic M., et al. (2004) J. Biol. Chem. 279:28393-28401
Wang Z., et al. (2004) J. Mol. Biol. 343:71-82
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