CLIC4, 1-253aa, Human

Catalog
01-1838-4
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Proteins, Recombinant
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Product Name CLIC4, 1-253aa, Human
Background CLIC4 (chloride intracellular channel 4), also known as H1, CLIC4L or MTCLIC, is a 253 amino acid single-pass membrane protein that localizes to both the nucleus and the cytoplasm and contains one GST C-terminal domain. CLIC4 functions as a monomer that is able to form selective ion channels in target proteins, thereby facilitating the transport of chloride and other ions. CLIC4 is thought to play a role in apoptosis and has been shown to translocate to the nucleus under stress conditions. Recombinant human CLIC4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms Chloride intracellular channel protein 4, CLIC4L, DKFZp566G223, FLJ38640, H1, huH1, MTCLIC, P64h1
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MALSMPLNGL KEEDKEPLIE LFVKAGSDGE SIGNCPFSQR LFMILWLKGV VFSVTTVDLK RKPADLQNLA PGTHPPFITF NSEVKTDVNK IEEFLEEVLC PPKYLKLSPK HPESNTAGMD IFAKFSAYIK NSRPEANEAL ERGLLKTLQK LDEYLNSPLP DEIDENSMED IKFSTRKFLD GNEMTLADCN LLPKLHIVKV VAKKYRNFDI PKEMTGIWRY LTNAYSRDEF TNTCPSDKEV EIAYSDVAKR LTK
Molecular Weight 19.1 kDa (171aa) confirmed by MALDI-TOF
Concentration 0.5 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_039234
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Malik M., et al. (2010) J Biol Chem. 285(31):23818-28.
Shukla A., et al. (2009) Nat Cell Biol. 11(6):777-84.

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