DOK4, 1-326aa Human

Catalog
01-P2595
$0.00
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Proteins, Recombinant
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Product Name DOK4, 1-326aa Human
Background DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. This protein is putative link with downstream effectors of RET in neuronal differentiation. DOK4 may be involved in the regulation of the immune response induced by T-cells. Recombinant human DOK4 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Synonyms docking protein 4, Downstream of tyrosine kinase 4, FLJ10488, IRS-5, IRS5
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSMATNFSD IVKQGYVKMK SRKLGIYRRC WLVFRKSSSK GPQRLEKYPD EKSVCLRGCP KVTEISNVKC VTRLPKETKR QAVAIIFTDD SARTFTCDSE LEAEEWYKTL SVECLGSRLN DISLGEPDLL APGVQCEQTD RFNVFLLPCP NLDVYGECKL QITHENIYLW DIHNPRVKLV SWPLCSLRRY GRDATRFTFE AGRMCDAGEG LYTFQTQEGE QIYQRVHSAT LAIAEQHKRV LLEMEKNVRL LNKGTEHYSY PCTPTTMLPR SAYWHHITGS QNIAEASSYA GEGYGAAQAS SETDLLNRFI LLKPKPSQGD SSEAKTPSQ
Molecular Weight 14.4 kDa (135aa) confirmed by MALDI-TOF
Concentration 0.5 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT.
Purity > 85% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_060580
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Hooker,E, et al. (2012) Biochem. Biophys. Res. Commun. 427 (1), 67-72
Gerard,A., et al. (2009) J. Immunol. 182 (12), 7681-7689

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