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|Product Name||EIF5A2, 1-153aa, Human|
|Background||EIF5A2, a member of eukaryotic initiation factor 5A subfamily, is an essential protein tightly linked to cellular polyamine homeostasis. The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond during the initial stage of protein synthesis. It seems to be the only eukaryotic protein to have a hypusine residue, which is a post-translational modification of a lysine by the addition of a butylamino group. Recombinant human EIF5A2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
|Synonyms||Eukaryotic translation initiation factor 5A2, Eukaryotic translation initiation factor 5A2, eIF 5A 2, eIF 5A2, eIF5AII, Eukaryotic initiation factor 5A isoform 2, eIF-4D, EIF5A 2, EIF5A2, Eukaryotic translation initiation factor 5A2, MGC124092, MGC124093|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MADEIDFTTG DAGASSTYPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDYQ LICIQDGYLS LLTETGEVRE DLKLPEGELG KEIEGKYNAG EDVQVSVMCA MSEEYAVAIK PCK|
|Molecular Weight||38.3kDa(353aa), confirmed by MALDI-TOF|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol|
|Purity||> 85% by SDS-PAGE|
|NCBI Accession #||NP_065123|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Guan XY., et al. (2010) Hepatology. 51(4):1255-63.
Luk JM., et al. (2009) Int J Cancer. 127(4):968-76.
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