GZMK, 27-264aa, Human

Catalog
01-P2294
$0.00
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Proteins, Recombinant
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More Information
Product Name GZMK, 27-264aa, Human
Background GZMK is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. Recombinant human GZMK protein, fused to His-tag at N-terminus, was expressed in E.coli.
Synonyms Granzyme K, TRYP2
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSIIGGKEV SPHSRPFMAS IQYGGHHVCG GVLIDPQWVL TAAHCQYRFT KGQSPTVVLG AHSLSKNEAS KQTLEIKKFI PFSRVTSDPQ SNDIMLVKLQ TAAKLNKHVK MLHIRSKTSL RSGTKCKVTG WGATDPDSLR PSDTLREVTV TVLSRKLCNS QSYYNGDPFI TKDMVCAGDA KGQKDSCKGD SGGPLICKGV FHAIVSGGHE CGVATKPGIY TLLTKKYQTW IKSNLVPPHT N
Molecular Weight 18.8 kDa (178aa)
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
Purity > 85% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_002095
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Rucevic M, Fast LD, et al. (2007). Shock. 27(5):488-93.
Zhao T, Zhang H, et al. (2007). J Biol Chem. 282(16):12104-11.

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