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|Product Name||HOXC11, 1-304aa, Human|
|Background||HOXC11 belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. HOXC11 binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. Recombinant human HOXC11 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||homeobox protein Hox-C11, HOX3H|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSMFNSVNL GNFCSPSRKE RGADFGERGS CASNLYLPSC TYYMPEFSTV SSFLPQAPSR QISYPYSAQV PPVREVSYGL EPSGKWHHRN SYSSCYAAAD ELMHRECLPP STVTEILMKN EGSYGGHHHP SAPHATPAGF YSSVNKNSVL PQAFDRFFDN AYCGGGDPPA EPPCSGKGEA KGEPEAPPAS GLASRAEAGA EAEAEEENTN PSSSGSAHSV AKEPAKGAAP NAPRTRKKRC PYSKFQIREL EREFFFNVYI NKEKRLQLSR MLNLTDRQVK IWFQNRRMKE KKLSRDRLQY FSGNPLL|
|Molecular Weight||28 kDa (250aa), confirmed by MALDI-TOF|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 7.5) containing 0.15M NaCl, 30% glycerol, 1mM DTT.|
|Purity||> 80% by SDS-PAGE|
|NCBI Accession #||NP_055027|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||McIlroy,M., et al. (2010) Cancer Res. 70 (4), 1585-1594
Zhang,X., et al. (2007) J. Cell. Mol. Med. 11 (2), 299-306
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