HSD17B8, 1-261aa, Human

Catalog
01-1807-8
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Proteins, Recombinant
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Product Name HSD17B8, 1-261aa, Human
Background HSD17B8, also known as estradiol 17-beta-dehydrogenase 8, belongs to the short-chain dehydrogenases/reductases (SDR) family. In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. It may play a role in biosynthesis of fatty acids in mitochondria. Recombinant human HSD17B8 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Synonyms Estradiol 17-beta-dehydrogenase 8, FABGL, HKE6, RING2
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MASQLQNRLR SALALVTGAG SGIGRAVSVR LAGEGATVAA CDLDRAAAQE TVRLLGGPGS KEGPPRGNHA AFQADVSEAR AARCLLEQVQ ACFSRPPSVV VSCAGITQDE FLLHMSEDDW DKVIAVNLKG TFLVTQAAAQ ALVSNGCRGS IINISSIVGK VGNVGQTNYA ASKAGVIGLT QTAARELGRH GIRCNSVLPG FIATPMTQKV PQKVVDKITE MIPMGHLGDP EDVADVVAFL ASEDSGYITG TSVEVTGGLF M
Molecular Weight 36.8 kDa (313aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 1mM DTT
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_055049
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Ando A., et al. (1996) Genomics. 35:600-602
Rotinen M., et al. (2009) Endocrinol 200:85-92

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