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|Product Name||IGF-1, Human, Recombinant|
|Background||The Insulin-like growth factor-1(IGF-1) is mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGF-1 is predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGF-1 belongs to the insulin gene family, which also contains insulin and relaxin. The IGF-1 is similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. This recombinant human IGF-I is globular protein containing 70 amino acids, and 3 intra-molecular disulfide bonds. Recombinant IGF-1 was expressed in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.|
|Synonyms||Insulin-like growth factor-1, IGF-IA, Somatomedin-C, MGF, IBP1, IGF1, IBP1, IGF-1, Insulin-like growth factor-1 IGF IA, IGF IB, IGF1, IGFI, IGFIA, Insulin like growth factor 1, Insulin like growth factor 1 (somatomedin C), Insulin like growth factor IA, Insulin like growth factor IB, Mechano growth factor, Somatomedin C,|
|Amino Acid Sequence||MGPETLCGAE LVDALQFVCG DRGFYFNKPT GYGSSSRRAP QTGIVDECCF RSCDLRRLEM YCAPLKPAKS A|
|Molecular Weight||104.1kDa (937aa)|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl pH8.0, 10% glycerol|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_000609|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Rinderknecht E., et al (1978) J Biol.Chem, 253: 2769.
Zumstein P., et al (1987) J Biol. Chem, 262: 11252.
Rabinovsky ED (2004) Neurol Res, 26: 204-210
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