MARCKSL1, 1-195aa, Human

Catalog
01-P2041
$0.00
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Proteins, Recombinant
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Product Name MARCKSL1, 1-195aa, Human
Background MARCKS-related protein, also known as MARCKSL1, is a member of MARCKS family of PKC substrate. It is widely used in the signal transduction studies as an indicator of PKC activation. Expressed in a variety of tissues with highest levels found in testis and uterus, MARCKSL1 participates in the coordination of membrane-cytoskeletal signaling events, including secretion, migration, phagocytosis and cell adhesion. Additionally, MARCKSL1 functions as a regulator of Integrin activation and is thought to regulate Integrin-dependent signal transduction pathways, especially those involved in macrophage spreading. Recombinant human MARCKSL1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms MARCKS-related protein, F52, MACMARCKS, MLP, MLP1, MRP
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSMGSQSSK APRGDVTAEE AAGASPAKAN GQENGHVKSN GDLSPKGEGE SPPVNGTDEA AGATGDAIEP APPSQGAEAK GEVPPKETPK KKKKFSFKKP FKLSGLSFKR NRKEGGGDSS ASSPTEEEQE QGEIGACSDE GTAQEGKAAA TPESQEPQAK GAEASAASEE EAGPQATEPS TPSGPESGPT PASAEQNE
Molecular Weight 33.8 kDa (302aa) confirmed by MALDI-TOF
Concentration 0.5 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% glycerol
Purity > 90% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_075385
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Jin T., et al. (2001) J Biol Chem. 276:12879-12884
Murphy A., et al. (2003) Neurosci Lett. 347:9-12.

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