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|Product Name||PINX1, 1-328aa, Human, Recombinant|
|Background||PINX1(PIN2-interacting protein 1) is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. This protein contains a TID (telomerase inhibiting domain) domain which is capable of binding MCRS1, TERT and TERF1. PINX1 has been shown to be a potent telomerase inhibitor and putative tumor suppressor. Recombinant human PINX1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
|Synonyms||PIN2-interacting protein 1, TRF1-interacting protein 1, Liver-related putative tumor suppressor, Protein 67-11-3, LPTL, LPTS, PINX1, PIN2-interacting protein 1 67-11-3 protein PIN2 interacting protein 1, Hepatocellular carcinoma-related putative tumor suppressor,|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEH GATDHIKVQV KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR QSKKTPEGDA SPSTPEENET TTTSAFTIQE YFAKRMAALK NKPQVPVPGS DISETQVERK RGKKINKEAT GKDVESYLQP KAKRHTEGKP ERAEAQERVA KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK KLQKPVEIAE DATLEETLVK KKKKKDSK|
|Endotoxin Level||< 1.0 EU per 1 microgram of protein (determined by LAL method)|
|Molecular Weight||40.5 kDa (369 aa)|
|Concentration||0.20mg/ml (determined by Bradford assay)|
|Form||Liquid, in PBS (pH 7.4) containing 10% glycerol, 1mM PMSF|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_060354|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Zhou XZ., et al. (2001). Cell. 107(3):347-59
Yoo JE., et al. (2009). J Mol Biol. 388(5):928-40
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