PINX1, 1-328aa, Human, Recombinant

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01-2074
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Proteins, Recombinant
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Product Name PINX1, 1-328aa, Human, Recombinant
Background PINX1(PIN2-interacting protein 1) is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. This protein contains a TID (telomerase inhibiting domain) domain which is capable of binding MCRS1, TERT and TERF1. PINX1 has been shown to be a potent telomerase inhibitor and putative tumor suppressor. Recombinant human PINX1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Synonyms PIN2-interacting protein 1, TRF1-interacting protein 1, Liver-related putative tumor suppressor, Protein 67-11-3, LPTL, LPTS, PINX1, PIN2-interacting protein 1 67-11-3 protein PIN2 interacting protein 1, Hepatocellular carcinoma-related putative tumor suppressor,
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEH GATDHIKVQV KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR QSKKTPEGDA SPSTPEENET TTTSAFTIQE YFAKRMAALK NKPQVPVPGS DISETQVERK RGKKINKEAT GKDVESYLQP KAKRHTEGKP ERAEAQERVA KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK KLQKPVEIAE DATLEETLVK KKKKKDSK
Endotoxin Level < 1.0 EU per 1 microgram of protein (determined by LAL method)
Molecular Weight 40.5 kDa (369 aa)
Concentration 0.20mg/ml (determined by Bradford assay)
Form Liquid, in PBS (pH 7.4) containing 10% glycerol, 1mM PMSF
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_060354
Host E.coli
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Zhou XZ., et al. (2001). Cell. 107(3):347-59
Yoo JE., et al. (2009). J Mol Biol. 388(5):928-40

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