RAN, 1-216aa, Human

Catalog
01-1853
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Proteins, Recombinant
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Product Name RAN, 1-216aa, Human
Background RAN, member RAS oncogene family, also known as RAN, is a small GTPase of the Ras superfamily that controls nucleocytoplasmic transport. It is involved in the directionality of the process that is regulated by GTP hydrolysis. Ran shuttles between the nucleus and the cytoplasm. Unlike many other regulatory GTPases, Ran is not posttranslationally modified so that it can be targeted to the subcellular compartment where it acts. Rather, RanGTP has been thought to be localized by the differential localization of Ran regulators. Recombinant human RAN, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques
Synonyms ARA24, Gsp1, TC4, RAN, member RAS oncogene family, Androgen receptor associated protein 24, ARA 24, GTP binding nuclear protein RAN, GTPase Ran, LPS, RAN member RAS oncogene family, Ras like protein TC4, RASL2 8,
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL VFHTNRGPIK FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN VPNWHRDLVR VCENIPIVLC GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS AKSNYNFEKP FLWLARKLIG DPNLEFVAMP ALAPPEVVMD PALAAQYEHD LEVAQTTALP DEDDDL
Molecular Weight 26.7 kDa (238aa), confirmed by MALDI-TOF
Concentration 0.5mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing, 20% glycerol
Purity > 90% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_006316
Host E.coli
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Woo IS., et al. (2008) Apoptosis. 13(10):1223-31.
Ren M., et al. (1994) Mol Cell biol. 14(6):4216-24.

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