RARalpha, 68-173aa, Human, Recombinant

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01-2307
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Proteins, Recombinant
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Product Name RARalpha, 68-173aa, Human, Recombinant
Background Retinoic acid receptors (RAR) belong to the large family of ligand responsive gene regulatory proteins that includes receptors for steroid and thyroid hormones. These proteins contain two highly conserved domains that are involved in determining their DNA and ligand-binding activities. Three isotypes of RARs, alpha, beta, and gamma, are encoded by distinct genetic loci and possess distinct transcriptional properties. Typically, RAR-alpha represses target gene transcription in the absence of hormone, whereas RAR-beta and gamma fail to repress under these conditions. Recombinant human RARalpha, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms NR1B1, Retinoic acid receptor alpha, Retinoic acid receptor, alpha isoform 1, RAR alpha, RARalpha, RAR, Retinoic acid receptor, alpha isoform 1
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MSEEIVPSPP SPPPLPRIYK PCFVCQDKSS GYHYGVSACE GCKGFFRRSI QKNMVYTCHR DKNCIINKVT RNRCQYCRLQ KCFEVGMSKE SVRNDRNKKK KEVPKPE
Molecular Weight 37.3 kDa (321 aa)
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 25 mM Tris-HCl, pH7.5, 2 mM beta-mercaptoethanol, 1 mM EDTA.1mMDTT, 20%Glycerol
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_000955
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Kliewer SA., et al. (1992) Nature. 355, 446-9.
Gillespie RF., et al. (2007) J. Biol. Chem. 282, 33421-34.

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