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|Product Name||SAR1A, 1- 198aa, Human, Recombinant|
|Background||SAR1a gene homolog 1, also known as SAR1A, belongs to the small GTPase superfamily. Sar1 is an essential component of COPII vesicle coats involved in export of cargo from the ER. The GTPase activity of Sar1 functions as a molecular switch to control protein-protein and protein-lipid interactions that direct vesicle budding from the ER. GDP-bound Sar1 interacts with the membrane-bound exchange factor Sec12 and exchanges its bound GDP for GTP. Recombinant human SAR1A, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||COPII-associated small GTPase, Masra2, SAR1, Sara, SARA1, SAR1a gene homolog 1 COPII associated small GTPase, GTP binding protein SAR1a, Masra 2, SAR 1, SAR1 gene homolog A, SAR1 homolog A (S, cerevisiae), SAR1A, SAR1a gene homolog (S cerevisiae) 1, SAR1a gene homolog 1 (S cerevisiae), SARA 1.|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MSFIFEWIYN GFSSVLQFLG LYKKSGKLVF LGLDNAGKTT LLHMLKDDRL GQHVPTLHPT SEELTIAGMT FTTFDLGGHE QARRVWKNYL PAINGIVFLV DCADHSRLVE SKVELNALMT DETISNVPIL ILGNKIDRTD AISEEKLREI FGLYGQTTGK GNVTLKELNA RPMEVFMCSV LKRQGYGEGF RWLSQYID|
|Molecular Weight||46.7 kDa (420 aa), confirmed by MALDI-TOF.|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol.|
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||NP_064535|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Jones B., et al. (2003) Nat Genet. 34(1):29-31.
Bi X., et al. (2007) Dev Cell. 13(5):635-45.
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