TCEAL7, 1-100aa, Human

Catalog
01-P1616
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Proteins, Recombinant
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Product Name TCEAL7, 1-100aa, Human
Background TCEAL7 plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. It associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. This protein regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres) and telomerase-positive cell lines. Recombinant human TCEAL7 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms Transcription elongation factor A (SII)-like 7, MPMGp800C04260Q003
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSHMQKPCK ENEGKPKCSV PKREEKRPYG EFERQQTEGN FRQRLLQSLE EFKEDIDYRH FKDEEMTREG DEMERCLEEI RGLRKKFRAL HSNHRHSRDR PYPI
Molecular Weight 15 kDa (132aa) confirmed by MALDI-TOF
Concentration 0.25 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol
Purity > 80% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_689491
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Lafferty-Whyte,K., et al. (2010) Neoplasia 12 (5), 405-414
Rattan,R., et al. (2010) Oncogene 29 (9), 1362-1373

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