| Product Name | UTP23, 1-249aa, Human |
|---|---|
| Description | rRNA-processing protein UTP23 homolog, also known as UTP23, is a small subunit (SSU) processome component. The SSU processome is a complex involved in ribosome biogenesis and is required for pre-18S rRNA maturation. UTP23 is required for the first three cleavage steps in 18S rRNA maturation. In addition, single-point mutations in the conserved putative active site of Utp24 but not Utp23 abrogate its function in ribosome biogenesis. Recombinant human UTP23 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | rRNA-processing protein UTP23 homolog, C8orf53 |
| Host | E.coli |
| Molecular Weight | 26 kDa (238aa) |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMKITRQK HAKKHLGFFR NNFGVREPYQ ILLDGTFCQA ALRGRIQLRE QLPRYLMGET QLCTTRCVLK ELETLGKDLY GAKLIAQKCQ VRNCPHFKNA VSGSECLLSM VEEGNPHHYF VATQDQNLSV KVKKKPGVPL MFIIQNTMVL DKPSPKTIAF VKAVESGQLV SVHEKESIKH LKEEQGLVKN TEQSRRKKRK KISGPNPLSC LKKKKKAPDT QSSASEKKRK RKRIRNRSNP KVLSEKQNAE GE |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
| References |
Bleichert F., et al. (2006) Proc Natl Acad Sci USA. 103(25):9464-9 Bernstein K A., et al. (2004) Eukaryotic Cell. 3: 1619-1626. |
| Supplier | ARP |
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