| Product Name | Chicken Transforming growth factor _1 (TGF-_1) ELISA Kit |
|---|---|
| Description | TGF-_ is capable of producing a variety of effects and virtually all cell types respond to this factor in some way. The inappropriate presence of active TGF-_1 has been implicated in a variety of pathological conditions Because of the necessity for regulating its activity tightly, TGF-_ is secreted by cells in the form of an inactive complex. This complex consists of TGF-_1 associated non-covalently with a protein designated the latency associated peptide (LAP). TGF-_1 and LAP represent components of a pro-peptide that is cleaved in a post-golgi compartment prior to secretion. LAP and TGF-_1 each consist of a disulfide-linked homodimer and the association of these two components renders TGF-_1 inactive and inaccessible to anti-TGF-_ antibodies. This assay has high sensitivity and excellent specificity for detection of Chicken TGFB1. No significant cross-reactivity or interference between Chicken TGFB1 and analogues was observed. |
| Synonyms | CED, DPD1, LAP, TGFB, TGFbeta, TGF-beta 1 protein|latency-associated peptide |
| Method | Sandwich ELISA |
| Detection Range | Request Information |
| Sensitivity | Request Information |
| Reactivity | Chicken |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
TGF-_ is capable of producing a variety of effects and virtually all cell types respond to this factor in some way. The inappropriate presence of active TGF-_1 has been implicated in a variety of pathological conditions Because of the necessity for regulating its activity tightly, TGF-_ is secreted by cells in the form of an inactive complex. This complex consists of TGF-_1 associated non-covalently with a protein designated the latency associated peptide (LAP). TGF-_1 and LAP represent components of a pro-peptide that is cleaved in a post-golgi compartment prior to secretion. LAP and TGF-_1 each consist of a disulfide-linked homodimer and the association of these two components renders TGF-_1 inactive and inaccessible to anti-TGF-_ antibodies. |
| Supplier | Abebio |
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