| Product Name | Bovine Resistin (RETN) ELISA Kit |
|---|---|
| Description | Resistin, a novel adipose-derived protein, has been proposed to cause insulin-resistant states in obesity. Resistin is produced by white and brown adipose tissues but has also has been identified in several other tissues, including the hypothalamus, pituitary and adrenal glands, pancreas, gastrointestinal tract, myocytes, spleen, white blood cells and plasma. Resistin antagonizes insulin action, and is down regulated by rosiglitazone and peroxisome proliferator-activated receptor gamma agonists. Resistin is elevated in patients with type 2 diabetes and may play a role in the vascular complications of this disorder. Recently, resistin has been discussed controversially as a missing link between obesity and insulin resistance. Bovine Resistin (RETN) ELISA Kit employs a two-site sandwich ELISA to quantitate Resistin in samples. An antibody specific for Resistin has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any Resistin present is bound by the immobilized antibody. After removing any unbound substances, HRP-Conjugate Bovine Resistin detection antibody is added to the wells. Following a wash to remove any unbound HRP reagent, a Chromogen solution is added to the wells and color develops in proportion to the amount of Resistin bound in the initial step. The color development is stopped and the intensity of the color is measured. |
| Synonyms | RETN, ADSF, FIZZ3, MGC126603, MGC126609, RETN1, RSTN, XCP1, C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1, found in inflammatory zone 3 |
| Method | Sandwich ELISA |
| Detection Range | 1.5 μg/L-24 μg/L |
| Sensitivity | 0.1 μg/L |
| Reactivity | Bovine |
| Sample Types | Cell culture supernatants, Serum, Plasma, Other biological fluids |
| Gene Id | 369020 |
| Storage | 2-8°C |
| Background |
Resistin, a novel adipose-derived protein, has been proposed to cause insulin-resistant states in obesity. Resistin is produced by white and brown adipose tissues but has also has been identified in several other tissues, including the hypothalamus, pituitary and adrenal glands, pancreas, gastrointestinal tract, myocytes, spleen, white blood cells and plasma. Resistin antagonizes insulin action, and is down regulated by rosiglitazone and peroxisome proliferator-activated receptor gamma agonists. Resistin is elevated in patients with type 2 diabetes and may play a role in the vascular complications of this disorder. Recently, resistin has been discussed controversially as a missing link between obesity and insulin resistance. |
| Supplier | Abbkine |
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