Dog Tumor necrosis factor receptor superfamily member 5 (CD40) ELISA Kit
| Product Name | Dog Tumor necrosis factor receptor superfamily member 5 (CD40) ELISA Kit |
|---|---|
| Description | is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40L plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40L has three binding partners: CD40, _5_1 integrin and _IIb_3.CD40L is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome. This assay has high sensitivity and excellent specificity for detection of Canine CD40. No significant cross-reactivity or interference between Canine CD40 and analogues was observed. |
| Synonyms | Bp50, CDW40, MGC9013, TNFRSF5, p50, B cell surface antigen CD40|B cell-associated molecule|CD40 antigen|CD40 antigen (TNF receptor superfamily member 5)|CD40 type II isoform|CD40L receptor|nerve gro |
| Method | Sandwich ELISA |
| Detection Range | 0.156-10 ng/mL |
| Sensitivity | 0.056 ng/mL |
| Reactivity | Canine |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40L plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40L has three binding partners: CD40, _5_1 integrin and _IIb_3.CD40L is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome. |
| Supplier | Abebio |
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