| Product Name | Human A Disintegrin And Metalloprotease 10,ADAM10 ELISA Kit |
|---|---|
| Description | A Disintegrin And Metalloprotease 10 is a ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. ADAM10 is a sheddase, and has a broad specificity for peptide hydrolysis reactions. New data on the ADAM10 shedding of ephrin/eph complex associated with Eph on one cell surface has determined that ADAM10 cleaves ephrin, within the ephrin/eph complex, formed between two cell surfaces. When ephrin is freed from the opposing cell, the entire ephrin/eph complex is endocytosed. This shedding in trans had not been previously shown, but may well be involved in other shedding events. This assay has high sensitivity and excellent specificity for detection of Human ADAM10. No significant cross-reactivity or interference between Human ADAM10 and analogues was observed. |
| Synonyms | AD10, CD156c, HsT18717, MADM, kuz, a disintegrin and metalloprotease domain 10|a disintegrin and metalloproteinase domain 10|kuzbanian |
| Method | Sandwich ELISA |
| Detection Range | 78.1-5000 pg/mL |
| Sensitivity | 28 pg/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | A Disintegrin And Metalloprotease 10 is a ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. ADAM10 is a sheddase, and has a broad specificity for peptide hydrolysis reactions. New data on the ADAM10 shedding of ephrin/eph complex associated with Eph on one cell surface has determined that ADAM10 cleaves ephrin, within the ephrin/eph complex, formed between two cell surfaces. When ephrin is freed from the opposing cell, the entire ephrin/eph complex is endocytosed. This shedding in trans had not been previously shown, but may well be involved in other shedding events. |
| Supplier | Abebio |
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