| Product Name | Human Acetyl-CoA carboxylase 1 (ACACA) ELISA Kit |
|---|---|
| Description | Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). ACC is a multi-subunit enzyme in most prokaryotes and in the chloroplasts of most plants and algae, whereas it is a large, multi-domain enzyme in the endoplasmic reticulum of most eukaryotes. The most important function of ACC is to provide the malonyl-CoA substrate for the biosynthesis of fatty acids. The activity of ACC can be controlled at the transcriptional level as well as by small molecule modulators and covalent modification. The human genome contains the genes for two different ACCs „ ACACA and ACACB. In muscle cells, malonyl-CoA inhibits beta-oxidation. This assay has high sensitivity and excellent specificity for detection of Human ACACA. No significant cross-reactivity or interference between Human ACACA and analogues was observed. |
| Synonyms | ACAC, ACC, ACC1, ACCA, ACC-alpha|acetyl-CoA carboxylase 1|acetyl-CoA carboxylase-alpha |
| Method | Sandwich ELISA |
| Detection Range | 3.12-200 ng/mL |
| Sensitivity | 1.09 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). ACC is a multi-subunit enzyme in most prokaryotes and in the chloroplasts of most plants and algae, whereas it is a large, multi-domain enzyme in the endoplasmic reticulum of most eukaryotes. The most important function of ACC is to provide the malonyl-CoA substrate for the biosynthesis of fatty acids. The activity of ACC can be controlled at the transcriptional level as well as by small molecule modulators and covalent modification. The human genome contains the genes for two different ACCs „ ACACA and ACACB. In muscle cells, malonyl-CoA inhibits beta-oxidation. |
| Supplier | Abebio |
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