| Product Name | Human Adiponectin Receptor Protein 1 (ADIPOR1) ELISA Kit |
|---|---|
| Description | Human ADIPOR1 also has 375 amino acids and shares 96.8% identity with the mouse protein. ADIPOR1 and ADIPOR2 are highly related structurally, and mouse Adipor1 and Adipor2 share 66.7% identity. ADIPOR1 and ADIPOR2 are 7-transmembrane domain proteins, but they are structurally, topologically, and functionally distinct from G protein-coupled receptors (GPCRs). Epitope tag labeling showed that the N terminus is internal and the C terminus is external in the ADIPORs, a topology opposite that of GPCRs. ADIPOR1 and ADIPOR2 are conserved from yeast to human, especially in the membrane-spanning regions. The authors noted that the yeast homolog has a principal role in metabolic pathways that regulate lipid metabolism, such as fatty acid oxidation. This assay has high sensitivity and excellent specificity for detection of Human ADIPOR1. No significant cross-reactivity or interference between Human ADIPOR1 and analogues was observed. |
| Synonyms | ACDCR1, CGI-45, CGI45, FLJ25385, FLJ42464, PAQR1, TESBP1A, |
| Method | Sandwich ELISA |
| Detection Range | 0.781-50 ng/mL |
| Sensitivity | 0.29 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background | Human ADIPOR1 also has 375 amino acids and shares 96.8% identity with the mouse protein. ADIPOR1 and ADIPOR2 are highly related structurally, and mouse Adipor1 and Adipor2 share 66.7% identity. ADIPOR1 and ADIPOR2 are 7-transmembrane domain proteins, but they are structurally, topologically, and functionally distinct from G protein-coupled receptors (GPCRs). Epitope tag labeling showed that the N terminus is internal and the C terminus is external in the ADIPORs, a topology opposite that of GPCRs. ADIPOR1 and ADIPOR2 are conserved from yeast to human, especially in the membrane-spanning regions. The authors noted that the yeast homolog has a principal role in metabolic pathways that regulate lipid metabolism, such as fatty acid oxidation. |
| Supplier | Abebio |
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