Human Amiloride-sensitive sodium channel subunit beta (SCNN1B) ELISA Kit
| Product Name | Human Amiloride-sensitive sodium channel subunit beta (SCNN1B) ELISA Kit |
|---|---|
| Description | The epithelial sodium channel (short: ENaC, also: sodium channel non-neuronal 1 (SCNN1) or amiloride sensitive sodium channel (ASSC)) is a membrane-bound ion-channel that is permeable for Li+-ions, protons and especially Na+-ions. It is a constitutively active ion-channel. It is arguably the most selective ion channel. Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This SCNN1b encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. This assay has high sensitivity and excellent specificity for detection of Human SCNN1B. No significant cross-reactivity or interference between Human SCNN1B and analogues was observed. |
| Synonyms | hCG_23853, BESC1, ENaCb, ENaCbeta, SCNEB, amiloride-sensitive sodium channel subunit beta|epithelial sodium channel beta-2 subunit|epithelial sodium channel beta-3 subunit|nasal epithelial sodium ch |
| Method | Sandwich ELISA |
| Detection Range | 0.312-20 ng/mL |
| Sensitivity | 0.107 ng/mL |
| Reactivity | Human |
| Sample Types | Serum, Plasma, Other biological fluids. |
| Background |
The epithelial sodium channel (short: ENaC, also: sodium channel non-neuronal 1 (SCNN1) or amiloride sensitive sodium channel (ASSC)) is a membrane-bound ion-channel that is permeable for Li+-ions, protons and especially Na+-ions. It is a constitutively active ion-channel. It is arguably the most selective ion channel. Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This SCNN1b encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. |
| Supplier | Abebio |
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