Human Anti-Glycyl tRNA Synthetase-antibody (GARS-Ab) ELISA Kit
| Product Name | Human Anti-Glycyl tRNA Synthetase-antibody (GARS-Ab) ELISA Kit |
|---|---|
| Description | Human Anti-Glycyl tRNA Synthetase-antibody (GARS-Ab) ELISA Kit has high sensitivity and excellent specificity for detection of Human GARS-Ab. No significant cross-reactivity or interference between Human GARS-Ab and analogues was observed. Glycyl-tRNA synthetase isone of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.Defects in GARS are the cause of distal spinal muscular atrophy type V (DSMA-V). DSMA-V is an autosomal dominant distal hereditary motor neuropathy (dHMN) with a phenotype similar to CMTD2. The main characteristic that distinguishes these disorders is the less severe distal sensory involvement in DSMA-V patients.Defects in GARS are the cause of Charcot-Marie-Tooth disease type 2D (CMT2D). This Human Anti-Glycyl tRNA Synthetase-antibody (GARS-Ab) ELISA Kit employs a two-site sandwich ELISA to quantitate GARS-Ab in samples. An antibody specific for GARS-Ab has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyGARS-Ab present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for GARS-Ab is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of GARS-Ab bound in the initial step. The color development is stopped and the intensity of the color is measured. |
| Synonyms | GARS-Ab, CMT2D, CMT2-D, DSMAV, GlyRS, SMAD1, EJ, Charcot-Marie-Tooth Neuropathy 2D, Glycine tRNA Ligase |
| Method | Sandwich ELISA |
| Detection Range | Please inquire |
| Sensitivity | Please inquire |
| Reactivity | Human |
| Sample Types | Cell culture supernatants, Serum, Plasma, Other biological fluids |
| Storage | 2-8°C |
| Background | Glycyl-tRNA synthetase isone of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.Defects in GARS are the cause of distal spinal muscular atrophy type V (DSMA-V). DSMA-V is an autosomal dominant distal hereditary motor neuropathy (dHMN) with a phenotype similar to CMTD2. The main characteristic that distinguishes these disorders is the less severe distal sensory involvement in DSMA-V patients.Defects in GARS are the cause of Charcot-Marie-Tooth disease type 2D (CMT2D) |
| Supplier | Abbkine |
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